VISIT WEBSITE FUNDAMENTALS EXPLAINED

DNA ligases seal 5′-PO4 and 3′-OH polynucleotide ends by means of a few nucleotidyl transfer steps involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are essential guardians of genomic integrity, and ligase dysfunction underlies human genetic disorder syndromes. Crystal buildings of DNA ligases bound to nucleotide and nucle